MOTIVATION: Small non-coding RNAs (sncRNAs, 800 curated experiments from ENCODE and GEO/SRA across multiple RNA-seq protocols for both GRCh38/hg38 and GRCh37/hg19 assemblies are integrated in DASHR. Moreover, DASHR is the first to contain both known and novel, previously un-annotated sncRNA loci identified by unsupervised segmentation (13 times more loci with 1 678 800 total). Additionally, DASHR v2.0 adds >3 200 000 annotations for non-small RNA genes and other genomic features (long-noncoding RNAs, mRNAs, promoters, repeats). Furthermore, DASHR v2.0 introduces an enhanced user interface, interactive experiment-by-locus table view, sncRNA locus sorting and filtering by biological features. All annotation and expression information directly downloadable and accessible as UCSC genome browser tracks.
AVAILABILITY AND IMPLEMENTATION: DASHR v2.0 is freely available at https://lisanwanglab.org/DASHRv2.
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
The Wang Lab at the University of Pennsylvania