Research

The Alzheimer’s Disease Sequencing Project (ADSP) was established in February 2012 as a Presidential Initiative to fight Alzheimer’s Disease (AD). Developed jointly by the National Institute on Aging (NIA) and the National Human Genome Research Institute (NHGRI), the specific aims of the ADSP are to 1) identify protective genomic variants in older adults at risk for AD, 2) identify new risk variants among AD cases, and 3) examine these factors in...

The Asian Cohort for Alzheimer’s Disease (ACAD) is an international collaboration with the goal of compiling a robust sample size of Asian American and Canadian subjects for Alzheimer’s disease (AD) research. Making up 6% and 10% of the US and Canadian populations respectively, Asians are the fastest-growing populations in both countries yet they are underrepresented in AD research. ACAD aims to address this gap by starting...

NIA Coordinating Genome Center of Alzheimer’s Disease (GCAD) is a five-year/$10.8M U54 Cooperative Agreement/Specialized Center funded by NIA (U54-AG052427) to facilitate AD gene discovery by coordinating analysis of all AD-relevant data. GCAD will assemble all data generated by the Alzheimer’s Disease Sequence Project (ADSP) from both the Discovery Phase and the Follow-Up Phase, and all data from non-ADSP sources. GCAD consists of three cores: Administrative (Core...

NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is a genetics data repository set up by the National Institute of Aging (NIA) to facilitate access by qualified investigators to genotypic data for Alzheimer’s disease (AD). We propose to expand NIAGADS into a one-stop shopping data warehouse and portal for AD genetics that reflects the latest advances in genetics research and high-throughput genotyping and next-generation sequencing...